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Research Projects
1/4 - Brain Fluid Dynamics & Targeted Drug Delivery (Supported by the Horizon 2020 Scheme)
We investigate fluid, molecular and therapeutic transport in the brain using multiscale mechanistic models that integrate tissue microstructure, anisotropic transport and poromechanics. Our goal is to optimise localised drug delivery and enable predictive, patient-specific treatment planning.
2/4 - Digital Brain: Imaging, Physics and AI (Supported by RAEng Research Fellowship)
We integrate mechanistic simulations, imaging-derived anatomy and tissue properties, and physics-informed AI to develop a digital brain for predicting transport, therapeutic response and disease-related changes, supporting precision medicine and image-guided intervention.
3/4 - Blood-Brain Mechanics & Brain Clearance (Supported by RAEng Research Fellowship)
We combine experiments, computational modelling and AI to investigate cerebral blood flow and its interaction with brain tissue. AI-based vascular segmentation and imaging-informed simulations help us understand cerebrovascular diseases and optimise treatments.
4/4 Engineering Localised Drug Delivery in Cancer Tissues (Supported by MRC)
Using multiscale modelling together with imaging and experimental characterisation, we seek to identify the physical mechanisms that limit therapeutic penetration in solid tumour and develop model-guided strategies for localised and precision drug delivery in tumours.
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